I took Silodosin for the urination issues. It started working within hours of my taking the first pill. I eventually had to be taken off of Silodosin much later as I experienced dizziness when quickly standing erect from either a sitting or reclining position which is one of the recognized side effects. The urination issues disappeared about a month or two after cessation of the proton treatments. I actually had the urination issues prior to proton therapy and was prescribed the medicine in an abundance of caution. One of the nice side effects of my experience with proton therapy is that my urination is now better than it has been in a long time. I understand that some individuals have had the opposite experience.