Hello... I too have thigh, knee and leg pain which is from hip osteoarthritis. But anti-inflammatories didn't work for the leg pain...Tylenol helps some. Through research of my own, I'm beginning to think it could be nerve pain, which is caused by hip osteoarthritis. Very painful to walk distance and sometimes painful to walk at all. I found a disease thru my research called Peripheral Artery Disease. It's a lack of blood flow to the legs. And the symptoms sound alot like your symptoms. Look it up and see what you think. It's just an idea....but I know how frustrating it is to not get answers and nothing you try helps! Good luck to you. Yes....I thought these were supposed to be our glory years too. I'm only 63....but hoping to get a hip replacement so I can get back to my active lifestyle.