Hello @mariajean03 I’m also taking seroquel 25mg at night but I don’t have nightmares . Are yo taking any other antidepressant? Did you check to see if the seraquel interacts with any of the other medications you’re on?

Hello @mariajean03,

You might consider talking to your doctor about trying Trazodone (just a small dose). I took it for years without the side effects that you mentioned. The only suggestion would be to take it earlier in the evening rather than right at bedtime. If I took it too late at night, I felt very foggy until about noon.

One way to be most successful with these types of meds is to start with a very low dose.

Mirtazapine (Remeron). It is a tetracyclic antidepressant that gives good sleep. It can increase appetite, so be careful there.

I think for brain issues, it would be wise to consult with a psychiatrist. I have a psychiatrist and I wouldn't want some other kind of provider prescribing head meds.