1. < Prostate Cancer

PALB2 Gene: How does this effect treatment and outcome?

Posted by cheriekhan @cheriekhan, May 24 12:06am

My partner who was diagnosed with stage 4 A prostate cancer just tested positive for the PALB2 gene. Will this decrease his chances of long term survival? He is going to be treated with radiation, ADT + injection and pill. The cancer is regional in the pelvic nodules and prostate.

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lisab2 | @lisab2 | May 24 10:02am

I don't know the answer on long-term survival per se. My husband has the same mutation and the oncologist said this mutation responds well to treatment with ATR inhibitors and immunotherapy. The oncologist sees this as a positive for treatment later.

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1 reply
cheriekhan | @cheriekhan | May 24 11:49am

Thank you this is so reassuring to hear.

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cheriekhan | @cheriekhan | May 26 8:25am
In reply to @lisab2 "I don't know the answer on long-term survival per se. My husband has the same mutation..." + (show)
@lisab2

I don't know the answer on long-term survival per se. My husband has the same mutation and the oncologist said this mutation responds well to treatment with ATR inhibitors and immunotherapy. The oncologist sees this as a positive for treatment later.

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Did your dr recommend this as the first line of treatment or after castration resistant?

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lisab2 | @lisab2 | May 26 10:47am

First line after castration resistant was Pluvicto.

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1 reply
cheriekhan | @cheriekhan | Jul 2 8:48pm
In reply to @lisab2 "First line after castration resistant was Pluvicto." + (show)
@lisab2

First line after castration resistant was Pluvicto.

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Was Pluvicto successful?

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lisab2 | @lisab2 | Jul 16 7:17am

After castration resistance, and after Pluvicto.

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