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PMR - Decreased prednisone and pain returned

Polymyalgia Rheumatica (PMR) | Last Active: May 28, 2024 | Replies (157)
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The lack of production of cortisol. The use of the steroids and the taper actually re-creates the PMR. This is from the NIH . Nat Institue of Health. sorry its in Dr language. "Cortisol dysfunction results in unmodulated inflammation following reactivation of the stress response, which may contribute to a cycle of inflammation, depression, and pain; pain is a stressor that may reactivate a proinflammatory stress response, now unmodulated due to cortisol dysfunction."

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Mike | @dadcue | May 25, 2024

Thank-you for this excerpt. Does the following link take you to the entire context?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263906/
I have skimmed this article. Where does it say, "The use of the steroids and the taper actually re-creates the PMR."

I was booted off another PMR forum for saying something similar to this. It reflects my opinion only which I clearly stated. Their position was that cortisol and/or *adrenal insufficiency" had nothing to do with relapses.

The following article spells it out in the Discussion Section:
https://web.archive.org/web/20220128061912id_/https://watermark.silverchair.com/roab091.pdf.

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