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PMR - Decreased prednisone and pain returned
Polymyalgia Rheumatica (PMR) | Last Active: May 28 1:36pm | Replies (157)Comment receiving replies
The lack of production of cortisol. The use of the steroids and the taper actually re-creates the PMR. This is from the NIH . Nat Institue of Health. sorry its in Dr language. "Cortisol dysfunction results in unmodulated inflammation following reactivation of the stress response, which may contribute to a cycle of inflammation, depression, and pain; pain is a stressor that may reactivate a proinflammatory stress response, now unmodulated due to cortisol dysfunction."
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Thank-you for this excerpt. Does the following link take you to the entire context?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263906/I have skimmed this article. Where does it say, "The use of the steroids and the taper actually re-creates the PMR."
I was booted off another PMR forum for saying something similar to this. It reflects my opinion only which I clearly stated. Their position was that cortisol and/or *adrenal insufficiency" had nothing to do with relapses.
The following article spells it out in the Discussion Section:
https://web.archive.org/web/20220128061912id_/https://watermark.silverchair.com/roab091.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAtIwggLOBgkqhkiG9w0BBwagggK_MIICuwIBADCCArQGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMKkw5HAVodIuOOGszAgEQgIIChRZdwI9xNVaeKkeZe7jJU29e41JdjlJegZPHLeIcXuFfxDL4_ClQCcYvNt6V_l53jpdEqiJ1nHLtropSDqcAWJyxfcQoOji4r9vXk8sISkXdcIYyIT5GMieXv-za3al1Avo11SVNV_kd2gtbitSYNr7hCjGUJ7vQ0FaT_Wquuy6p5qeZmxQ2SsxnEu8FBvG4ggQn3rRed8sF56brf4JS3WZj6v5CfalNZJfI2zvqCOB8260V5LCCxIPUQXni5fU3hGLc9N3GPJfA-dK3lB9WuD6fY4JRaRy3mrF9UE7s_LmWAMWbsKguxog9ZYrx0SghOpuPFqEuED0dV-8VNN7m4CKZ87O1BH3WJTxYbX90gVI6H0B9dU8EQMGgVV8_9cV4_Q0LcWvdT7t7u2L6wcOMYqSrM8t3ShzxVsWbxgDG3T7yl5LJYrHDpvVvSqFOy40LlsyShYkqDgH7K4baJEa8XG2ufa1OkWAvF2hC6ksIQ4ttKh9LsfRgKhvG_kqkoiTUlvFGHl8KPN_8I3QNSfY-qFKatySkmY1jqAGsnhyeUgG-kW_U3UT0taF5oHPjwJ2l842ucIhtcqyzzIJtojR-sBqZoyAuXLUfADKB8ULUu_e8xRHJkVHLtR4QN0DNo1DtYWLKjMAjhqOWYceY7_Vivb635cagTqFG9_lkJM6MIxuHr7-SlobUtBsDt1OblfHN0vxL3yTP027pNGxB2Lb5MgS1xzvGAh8T1lH_9D3vczZSUwIhnV_FMZ7ps2iRPvq-en2Y7V7t2cGL9LussoNdi0rKuFIZNfqPrLhhwsbuiuoobANURuZxe7st3I8q4xIvTlyDN85V6X3AX6dtPEhYOO-2PNwXrg#:~:text=Relapses%20are%20common%20in%20patients,ficult%20to%20distinguish%20%5B20%5D.