I Too have been recently diagnosed with mesenteric panniculitis and have gained weight. It is really strange to me because I actually eat less now than I ever have. I noticed the bloating around my abdomen and the pain I have comes from my flank (lower right back around to my right groin area). The fatigue is really unbearable. I haven't been able to find anything that helps. I was recommended to this site by one of my contacts on the mesenteric panniculitis so I was hoping for some insight. I have an appt with my GI this upcoming week. If I come back with any information about the weight gain or the fatigue I will certainly pass them along.