From what I have read the estrogen creme I plan on getting from the doctor is low dose and since it is vagina it is not systemic to the rest of the body. I had DCIS which means cancer cells are contained and have not spread and I had stage zero grade 2 which many women who had this often just do a wait and see approach and do have have surgery. I did not require radiation or chemo after the lumpectomy and most of the cancer cells were removed when I had the biopsy done. I was on HRT for over 20 years and have no history of breast cancer in my family has I had genetic testing done. Not much of estrogen creme if used vaginally is absorbed throughout the body and at my age I don't think it matters.