I was first on Amitiza, zippo.
Next Linzess, helped some.. I was on 145mcg 2x day.
Now, Trulance, same as Linzess, different name and cheaper for my insurance.
17 years of CIC, same GI specialist...who neglected to mention that my CIC was so bad that I would need to keep using megadoses of miralax also.
I am assuming you must have bad CIC...if that is the case, read up on Hyperparathyroidism and elevated calcium. I went to 3 drs before I started to believe that I really did have this problem and that it wreaks havoc on smooth muscles in the whole body, my colon no longer contracts-release to push 💩 out. So, I have to keep my bowels in constant fluid/diarrhea, or it is not going to come out. I use 3-6 capfuls of miralax a day and throw in some Metamucil powder or gummy's a couple of times a week. I never leave the house cuz I don't know what might happen or not happen. Good luck. I have surgery in 3 weeks to remove probably 3 1/2 of the 4 parathyroid glands.