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PMR - Decreased prednisone and pain returned

Polymyalgia Rheumatica (PMR) | Last Active: May 28, 2024 | Replies (157)
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@abbeyc

Does anyone know or think Prednisone can cause (permanent?) muscle damage?

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Replies to "Does anyone know or think Prednisone can cause (permanent?) muscle damage?"
DadCue | @dadcue | May 23, 2024

Corticosteroid induced myopathy happens but the damage usually isn't permanent.
https://pubmed.ncbi.nlm.nih.gov/32491663/
Minimizing dose and duration of treatment is the most important safeguard to prevent this.

"Glucocorticoids have a direct catabolic effect on muscle, decreasing protein synthesis and increasing the rate of protein catabolism leading to muscle atrophy."
https://www.physio-pedia.com/Myopathy_Steroid_Induced

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