@gsgambhir, Ugh... sorry to hear of your wife's experience; extremely disappointing. Looks like those of us who show up at the LC clinics are mostly guinea pigs for research. Helps to know research is happening, to become aware of how little effective treatment has resulted so far, and to keep our expectations low. Many who post here have seen doctors who order tests and treatments with little or no improvement, brief remissions and/or side effects of drugs resulting in more harm than good. My extensive research doesn't show much that's definitive. I've had LC for 14 months now and the only thing that's improved is my grudging acceptance of the need to "pace," and of the fact that I seem to have a debilitating chronic illness and need to learn to live with it while not giving up hope for effective treatment. I will be seeing Dr. Karolnik in September, if they don't cancel again, and I'll let him know I'm not in pain and I can't swim. We'll see what he does with that.