With the GI issues previously stated, one has to always be alert to deal with previously caused factors day to day. So distinguishing the last 3 items you mentioned @abob from anything new is always difficult. He never has had appetite problems and of the last 3, we were able to attribute any issues to previous items, I mentioned and deal with them. No GI issues were contributed by Keytruda. After a difficult time with an antibiotic, he did have tests to assure all that there were no Keytruda issues which demonstrated no relationship to Keytruda. The Creon dose needed raised which resolved the issues. A great health care team giving support is so important. Thank you for asking. I hear you, as we initially sat considering Keytruda use and stared at the chart showing the potential side effects we wondered how it would go. Clearly any one of the cited side effects on that chart could happen or not at all. Everyone is different. We looked at our alternatives and he continues to be glad he used Keytruda.