I hope you get some responses. I took it 3 days and had no reaction. I read on this site that it takes 2 weeks to kick in and I don’t have 2 weeks to wait near a bathroom. So, I doubt I’ll try it again.

I was first on Amitiza, zippo.
Next Linzess, helped some.. I was on 145mcg 2x day.
Now, Trulance, same as Linzess, different name and cheaper for my insurance.
17 years of CIC, same GI specialist...who neglected to mention that my CIC was so bad that I would need to keep using megadoses of miralax also.
I am assuming you must have bad CIC...if that is the case, read up on Hyperparathyroidism and elevated calcium. I went to 3 drs before I started to believe that I really did have this problem and that it wreaks havoc on smooth muscles in the whole body, my colon no longer contracts-release to push 💩 out. So, I have to keep my bowels in constant fluid/diarrhea, or it is not going to come out. I use 3-6 capfuls of miralax a day and throw in some Metamucil powder or gummy's a couple of times a week. I never leave the house cuz I don't know what might happen or not happen. Good luck. I have surgery in 3 weeks to remove probably 3 1/2 of the 4 parathyroid glands.

I had a high calcium blood test and my Internist sent me to a Thyroid/Parathyroid surgeon (that is all he does). He performed an ultrasound in the office and results showed one gland the size of a grape and the others were normal, size of a grain of rice. He removed the grape sized gland, and I had immediate results the next day from one of the symptoms and over a few months the others subsided. Good luck and know that all the crazy symptoms that make you wonder if you ARE crazy, because they come and go and don't all occur at the same time, will go away.