Hi @mollie2, I have experience with a different targeted therapy, for an ALK mutation, not EGFR. Targeted therapies can have life threatening side-effects and other debilitating side-effects. I've found that the debilitating side effects can sometimes lessen over time. For some people reducing a dose can be helpful, but still very effective. From the ALK perspective, a reduced dose is not uncommon at all, but there's not a lot of published research around this because the medications are relatively new when compared with traditional chemo, especially for early-stage lung cancers. The clinical trials for these meds often lock in a dose early in the trial, and the researchers don't have much chance to change it without starting over. The FDA is starting to make the process more flexible which will help with dose ranges for future medications.
You can't sustain being miserable for the next number of years. Hopefully your oncologist may have suggestions to deal with some of the side effects, and hopefully they are able to present you with options.
Have you had a chance to speak with your doctor about what you're experiencing?