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Stage 4 CKD

Kidney & Bladder | Last Active: Jul 22 9:58pm | Replies (13)

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@cehunt57

@b2byrne I replied too soon. I am no reading the Mayo Clinic Essential Diabetes Book by M. Regina Castro M.D. It is available from Mayo Clinic Press. In it is an appendix on non insulin medication for Diabetes. Hang on, I know that you aren’t Diabetic but I found the Dapaglifozin in there. I do know it after all. The brand name is Farxiga. It is currently heavily being advertised on TV etc. This is what I learned about it and it might apply to you after all. It is in a class of drugs called
SGLT-2 inhibitors. It works by “causing urinary loss of glucose and salt.” Main advantages are that “some of these agents reduce the risk of heart attack, stroke, kidney failure, heart failure and death; possibly improve fatty liver.” The main disadvantages / side effects are “increased frequency of urination, dehydration, urinary infection, genital yeast infection, diabetic ketoacidosis; can be expensive”. Your nephrologist might be on to something. Could you ask him to explain the reasoning behind his recommending this med?

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Replies to "@b2byrne I replied too soon. I am no reading the Mayo Clinic Essential Diabetes Book by..."

Hi,

You have highlighted everything I know about Dapaglifozin. It was the pages and pages of side effects that worried me sick including possibility of death. I read and read and perhaps I should not have. The Nephrologist gave the positive reasons you explained above.
Having spoken to another GP who has had patients on Dapaglifozin I have decided to move forward. The GP said over the three years that she has seen patients on this medication the frequent side effects have been urinary infections. That does worry me, but I have tried to weigh up the odds. At the moment I am up 4 / 5 times a night to urinate sometimes more so deep sleep is minimal. I am hoping that doesn't get worse.