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Post prostatectomy: What do rising PSA levels mean?

Prostate Cancer | Last Active: May 26 4:55pm | Replies (188)
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@michaelcharles

Challenging to respond w/o practicing medicine w/o a license.
My 1st postop PSA was .19. Target was < .01.
Referred to Radiation Oncology for salvage treatment of radiation to the prostate bed/floor and pelvic lymph nodes and short-term ADT (see SPPORT trial).
My understanding is that steadily rising PSA (2 or more consecutive tests) and negative PSMA PET scan suggest cancer cells most likely remaining in the pelvic region.
And treatment considered when the PSA rises to or above .2

Good wishes to you.

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Replies to "Challenging to respond w/o practicing medicine w/o a license. My 1st postop PSA was .19. Target..."
ecurb | @ecurb | May 20 2:53pm

My medical oncologist says PET scan shows nothing if PSA < 4.0. Cancer cells can exist on the head of a Pin.

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michaelcharles | @michaelcharles | May 21 8:21am

Correction: Post RP PSA target < .1
(not < .01)
Following Salvage Treatment Rad Onc ordered Ultrasensative PSA testing and 6 and 9 mos uPSA has been < .02 (Quest Labs limit of detection therefore deemed "undetectable").
Coincidentally, had uPSA blood draw this morning for 3rd post treatment uPSA, now 12 months since Salvage Tx completed May/June 2023.
Best to all.

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