@1soc1soc, I've been on Tagrisso for 3 and a half years now. My Oncologist has always said he plans to keep me on it "until the negative side effects become unbearable." Not being able to afford it is one of those negative effects. But the possibility of heart damage with long-term use is right up there. I pressed him for details and he said it can either be muscular or electrical degeneration. At first, I was getting MUGA scans every 3 months, along with my brain MRI, CAT scan, and bloodwork. In my case, he stopped my MUGA scans after 2 years because my ejection fraction actually went up; plus, I'm also seeing a Cardiologist who has taken over monitoring my heart.

I haven't seen a study linking Tagrisso to short-term heart problems, but there is a link, and everybody's body is different.

If you have the time to do your own research, you can join the International Association for the Study of Lung Cancer at iaslc.org. Check out 'Lung Cancer 360' for more information than any of us lay people could ever process! The field is advancing very rapidly. Best of luck to you.