I have dealt with RLS for many years (almost 70). I seem to have found a solution in taking two .125mg Pramipexole pills at 6:00 each night, as well as before boarding any flights (where I’ve also had RLS occur). I’ve tried creams and warm showers and other meds, but this works for me. Key is to take it early (I have my Apple Watch alarm set each night) and to keep a supply available. When I forget because we went out somewhere and I don’t have any pills, I can still get an RLS incident and then take a couple of pills, but they may not be effective for 1.5-3 hours.

Good luck! It has been a huge relief for me to find what for about 6 months now has been a largely reliable solution.