Each person is different with individual risks, sensitviites and overall health concerns. Therefore I cannot answer your questions and encourage you to check in with other docs for secondary consult. Just make sure they are bone specialist. . Both drugs you mentioned are very strong . From what I know, Prolia is basically a lifetime drug - very hard to get off of and does not have reseasrch beyond 15 - 20 yrs, So if you are young be aware. Reclast is very strong - and has a higher half life ( time in body can be ten years) than other bisphosphanates. The less strong bisphosphanates ( ex fosamax) may be an option. Whatever you are choose, make sure the docs are checking bone markers. Please do make a decision on injection vs oral . Choose based on what is right for you. Get an overall health workup. Eat well, Quell inflammation - check gi and do everythign you can to establish good foundational health. There is a great book call 'Great Bones' just pulished by K McCormick. Read it well and it will guide you to ask the questions of your docs.