Evenity effectiveness after stopping Prolia

From what I have read in "Great Bones" and seen on videos like Dr. Ben Leder's "Combinations and Sequencing," only Reclast (and possibly alendronate, but that is less potent) can be used to prevent rebound after Prolia- unless you have had only two or three shots.

Evenity is fairly new and there needs to be more research on it in general, and more experience on the market. It inhibits sclerostin. Your doctor could explain whether that mechanism would be risky after Prolia. Evenity is an anti-resorptive in the second 6 months.

Thank you for your reply. I have understood that also. I have been looking for other studies that would have more definitive information about it. I haven't see very many others. I was wondering if others may have had more information about it. I did see a individual case report,"Romosozumab was not effective in preventing multiple spontaneous clinical vertebral fractures after denosumab discontinuation: a case study by Masafuni Kashii et.al. stating no suppressive effects during the rebound in BTM after discontinuation of denosumab located in BONE REPORTS 13 (2020).

Amgen manufactures both Prolia and Evenity. They've done research on Prolia following Evenity that shows continued increase in BMD, so they promote that sequence. Why wouldn't they when it increases their bottom line. Because they would also stand to benefit if Evenity treatment following Prolia were effective, I infer that they would promote that sequence as well.

i have read a paper that showed small overall 0.9% gain in hip and something like 5% gain in spine, with evenity following prolia,
but sorry i can't find the link.

what the paper doesn't give is month by month numbers;
i've been told that stopping prolia and starting evenity has an initial decline in bmd before starting gains. i don't know what the details are.

... so my concern would be that if a patient gets an ill-effect that requires them to stop (and resume prolia (or something - ?)) in the early months of evenity, they would be in the middle of worse numbers than when they started evenity.

having said that, my Mum's 80+ y.o friend had good results with a year of evenity after stopping about 8 years of prolia.
even had a fall off a chair and is ok.
so that's quite a review!