I concur with "being tired of dealing with CIC". So many people, especially doctors, really don't comprehend how all awful and all consuming CIC is. I have learned that all of the meds like Amitiza, Linzess, Trulance definitely do not work rapidly. I have had them all, barely any improvement, if any, since I have to stay on miralax. It takes 1-2 weeks to get any affects. I also learned that these meds most often can't handle CIC on their own; miralax, etc are very commonly needed too. Unfortunately we all probably have differing causes for CIC. For example: I don't increase fiber, unless it's followed with huge increases in fluid and miralax. I'm 65, with too many other factors that are contributing to my CIC. I am kind of on a warning track: if anyone has treatment resistant CIC, get your calcium, vitamin D and PTH tested. Hyperparathyroidism/elevated calcium can be a MAJOR contributor for CIC. Also it wreaks havoc on our smooth muscles..colon contractions...intestinal slow motility also. Check it out. I know it is not the answer for everyone, my GI and Endocrinologist of 17 years, neither ever mentioned this to me, until I asked a question about my pancreas and my endocrinologist suggested my calcium levels had been trending upward...bad for the body. But she still said to wait and see. My 2nd opinion and 3rd opinion, was way different. Best of luck to you.