I take that one, it was ok at the beginning but now is getting pretty bad. I have had constant nausea and back/bone/joint pain. The pain is the worst, I live on a heating pad when I’m at home and work ( Hygienist) is getting very hard to do with the pain in my back and hands. Doctor said I have limited options for the AI due to my age so I’m still trying to figure out what I want to do. What about you?

I've been on all three, Exemestane, Anastrozole and Letrozole. I was only on Exemestane for 30 days as my insurance didn't cover it. From comments I've seen on Connect it seems as if Exemestane possibly has the worst side effects. But everyone is different, so who knows how anyone would react. My suggestion would be to discuss with your oncologist switching to one of the other AI's. My knees got horrible after a year on AI's so I started taking collagen supplements (I prefer the capsules). They are back to normal, but I still have back and torso pain. I now wonder if that is (partially?) the Prolia I'm also on. Fingers crossed you find relief somewhere.

Good morning . I’m 61 and on anastrozole after lumpectomy/reconstruction and 15 rounds of radiation. It put me in a tail spin mentally and physically… probably had almost every side effect.( more details if you want/need). Took a vacation from the drug and felt better in about 3-4 weeks. I’m 99% estrogen/ progesterone positive. I got more supports in place from MD Anderson- but living 3hrs away some I couldn’t do( massages, acupuncture)but healthy yoga was a zoom class. I started exemestane… I ended up with ,insomnia, fatigue and severe hand joint pain…I took about a month break. I was able to find an acupuncturist close to me and have been doing that weekly for a month, and restarted Exemestane. My acupuncturist is also an oncologist and is holistic. She suggested a few more supplements. I am currently sleeping well and hand joint point( I have mild arthritis in hands)back to what it was. I am hoping to be able to stay on drug with success this time. I do and have been eating better, not drinking much, continuing yoga and walking- now about to swim because pool is warm enough 😊. I have bone density test and check up in June.
The acupuncture has been such a blessing for me mentally and physically. Sleeping again!!!

* everyone is different- I have several friends that had no side effects from anastrozole.