my oncologist informed me that there are original tagrisso trial participants that are still on tagrisso 8 years down the road. i will assume these people are overall healthy. i was healthy with no health problems and/or co-morbidities when i was diagnosed. since then, i have completely stopped drinking alcohol and always make sure i am eating very healthy. my oncologist used to be pessimistic and/or never said much in terms of my treatment. now he is way more optimistic than i actually am. the clinical trial that is ongoing may be only in phase 2 trial, but it will target all mutations along the egfr protein line. i am l858r. tagrisso was the first drug to completely cross the blood brain barrier and target the t790m mutation. this new drug will be a complete game changer because of it's ability to target all mutations along the egfr line. also, when i first started tagrisso, i was also tiring easily and exhibiting chest tightness due to my erratic heart rates. i have had numerous ekgs and a 48 hour holter monitor showed no arrthythmias. i still to this day occasionally, and for no apparent reason, my heart rate can shoot to the 140 range at the drop of a hat lasting only around a minute or two then immediately fall back to the 70s range. i use a pulse oximeter to measure the rapid rise and fall of my heart rates. i just recently had a severe bout of digestive issues, which i am attributing to possible long term tagrisso. next week i am going in for my chest ct, but a abdominal series was added with barium to rule out anything that could possibly be suspicious. do not worry that the tagrisso will stop working. sounds like your husband is going through the 'normal' process and side effects of tagrisso. one only hopes that the side effects are not severe enough to warrant removal from this drug. i started on a clinical trial and was in the control arm 'tagrisso only' participant with the addition of avastin being the other arm. so i have only known tagrisso since being diagnosed. i never had traditional chemotherapy. of course, my immune system is shot, just like traditional chemo, but i wear masks in any social situations and am as careful as humanly possible in order to not get sick. teresa