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@billfarm

After reading the synopsis of the titan trial it seems conclusive that synergy is demonstrated. Do you know of any research that compares xytiga/earleda effectively ranking efficacy?

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Replies to "After reading the synopsis of the titan trial it seems conclusive that synergy is demonstrated. Do..."

Unfortunately, I do not know of any studies comparing Xytiga and Erleada, but to be fair, I haven't needed to look. If there are any, they would have to be for your specific situation: localised or (oligo-)metastatic, castrate-sensitive or castrate resistant.

Erleada is the first ARSI they put me on (olgo-metastatic, castrate-sensitive), and together with emergency debulking surgery to the metastasis site on my spine, radiation and ADT, it's held my PSA at < 0.01 on the sensitive test for over 2½ years now, so my onco team and I haven't talked about any alternatives.

My radiation oncologist says that I'm in "remission", but I'd add a footnote that it's *medically-induced* remission — I don't know what would happen if I stopped the ADT and ARSI, and since I'm tolerating them well and living almost a normal, active life, I'm not interested in taking the risk of finding out.