I am on orgovyx 15 months now. Psa fell to undetectable in 3wks or less. Also taking generic zytiga. A few hot flashes and sweating and some fatigue. I have been resisting radiation not wanting to damage my current quality of life. The experts say the cancer will become resistant to adt sooner or later. There no long term studies on orgovyx as it was only approved Jan 2021 so they are just speculating on this one.