thanks for the information and i will look it up. i was a registered nurse for 30 years and many of these targeted therapy drugs are still too new for an oncologist to obtain a full grasp of what may or may not occur when someone starts tagrisso. i was told initially several months into treatment that there are no side effects listed for increased heart rates by my oncologist. i told him to throw the tagrisso manual in the trash because the drug is still too new to be going by government guidelines on what side effects may occur. after a 48 hour holter monitor and findings of pulse rates going from the 50s to the 130 range, my oncologist called the ones making the guidelines and sure enough, there have been a few others reporting increased heart rates from tagrisso. several months later, they changed the guidelines that included increased heart rates as a side effect. i will let my doctor know that tagrisso and zofran do not mix. thanks again. teresa jarvis