SGLT2 inhibitors in T2 diabetes without proteinuria

Posted by abid @abid, May 8 5:46pm

Are SGLT2 inhibitors indicated in T2 diabetes with reduced eGFR but no increased ACR. I read a British textbook Davidson's principles and practice of medicine in which in the algorithm of treatment of Type 2 DM, it is said that in case of reduced eGFR or reduced EF, SGLT2 inhibitors should be started irrespective to baseline HbA1c or target HbA1c.

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Cheryl, Volunteer Mentor | @cehunt57 | May 10 1:37pm

@abid welcome to Mayo Clinic Connect. Wow your discussion is full of acronyms (full disclosure, I don’t do well with acronyms). I will try to respond to the best of my ability. You are wondering about the use of SGLT2 inhibitors (a medication ?) in T2 (type 2) diabetes? You also have reduced eGFR (lowered kidney function) but no increased ACR (creatinine?)? You are also wondering the appropriateness of starting this medication in relation to your HbA1C (glycosylated hemoglobin)? Am I understanding your question correctly? All I can say about this is that if you have questions regarding medications for diabetes &/or kidney functions these concerns need to be brought to the attention of your providers. Do you have an endocrinologist &/or a nephrologist?