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CTX Marker

Osteoporosis & Bone Health | Last Active: Oct 6 11:06am | Replies (77)

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jbfm@jbfm
CTX numbers aren't useful in isolation.
The number represents actual particles that are left in your serum when osteoclasts break down bone.
Since those osteoclastic cells are attracted to fissures and weakness in the bone and rush in to clear those areas so that the cell that rebuild bone don't rebuild over a weakened structure, we should be happy with elevated numbers especially as we age. But we also need (to see P1NP bone marker evidence of) bone restoration.
njhornung's response is an important reminder to be wary of simplistic answers. The normals for women 50 to 59 years of age are so high because they are losing the most bone of anyone on the chart. Normal, but its like measuring the "normal number of fractures." "Normal," in this example. isn't advantageous or heathy.
Your CTX is likely high after two years of Forteo. And your P!NP is keeping up with it, giving you good strong bone. After stopping Forteo both numbers will drop. After a month you may be in an excellent position to take Tymlos or retake Forteo. A second application of Forteo is said to be as "robust" as the first. Initally Forteo causes a large jump in the number of bone building cells. Later in treatment the osteoclasts catch up and then we are advantaged by a pause in treatment.

A rather separate point: when we exercise with weight or participate in any impact activity, running, jumping. CTX rises as a functional adaptation to stress. The spicules in our bones actually realign according to our activities by breaking down and rebuilding. Lastly, if you have a broken bone CTX levels can be off the charts, because they are the first step of repair.

You are on the best track. Well, we're on the same track. You're a year ahead.

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Replies to "jbfm@jbfm CTX numbers aren't useful in isolation. The number represents actual particles that are left in..."

Wow. Thanks so much for this. My bone density tests showed a decrease after 6 years of no meds and my recent blood test showed a CTX 476 number which I couldn't interpret. The Dr who read the report wrote Normal - I ordered the test online and paid for it myself. My endocrinologist thought it useless.
She felt at my last visit that I shouldn't take Forteo again because of the black box label however I know that's been removed.
My only issue remains the same as it was 6 years ago after Forteo. I can't take Fosamax or Actenol and I refuse to take Prolia. This leaves Reclast and I've read horror stories of long-term effects.
My last bone density showed no change but my spine is -4.0.
I exercise and walk daily and am tempted to stay off meds altogether. Any advice?