My son has APS since 2007. He has been on warfarin since 2007 with exception of being on pradaxa short time. He has had at least 3 TIA’s, aortic heart valve replacement 2020 and awaiting another aortic heart valve TAVR hopefully within a few weeks. He’s 53 and he also has diabetes 2. He is not on any drug current or since diagnosis for APS except warfarin. As far as hydroxychloraquine, I never knew that drug was an option for APS until now after reading some of these comments. I am his mother and took hydroxychlorquine (placqunil) for many years for rheumatoid arthritis. Never had a problem or side effects with that drug. Last 8 yrs I’ve been taking rituxan for rheumatoid. Works great! I am so glad to have stumbled upon this site/blog. Learning a lot about APS. I think you’ll be just fine taking placqunil. I do hv a question, does anyone with APS experience painful hands/feet or “burning” pain on back of your tongue? Son experiencing those problems now and don’t know why or how to treat. Thanks and prays for all with APS!