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Has anyone used the drug 5 FU vaginally for VAIN 3?

Gynecologic Cancers | Last Active: May 10 7:32am | Replies (11)
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@brandysparks

I can reply with this for now:

Vaginal intraepithelial neoplasia (VAIN)
(as opposed to VIN, which is Vulvar Intraepithelial Neoplasia)

VAIN 3 means the full thickness (100%) of the surface layer of the vagina is affected. VAIN 3 is also called carcinoma in situ, but it is not vaginal cancer.

Macmillan Cancer Support
https://www.macmillan.org.uk › worried-about-cancer

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Replies to "I can reply with this for now: Vaginal intraepithelial neoplasia (VAIN) (as opposed to VIN, which..."
brandysparks | @brandysparks | May 9 7:58am

Also, here is a link to more info on this cream:
https://my.clevelandclinic.org/health/drugs/19329-fluorouracil-5-fu-skin-cream-or-solution
It is something my dermatologist gave me in ointment form (in a tube) to apply to my nose when I had a recurring keratosis. I am not a medical professional, but having been through some procedures for a precancerous (vulvar) condition, I personally would wonder how fluorouracil - (which is basically a chemotherapy drug, my former PCP advised me) - could be safe (or at least, not painful or erosive) to gynecologic tissue?

Again, just me, but I might doublecheck with another doctor / gynecologist or dermatologist before applying.

Best wishes.

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Helen, Volunteer Mentor | @naturegirl5 | May 9 8:02am

@brandysparks Thank you for the explanation. I can't recall anyone in our Gynecological Cancers support group posting about Vaginal intraepithelial neoplasia (VAIN). Can you? I'd like to refer this new member to other discussions. For now I will suggest this:

@randinc11 I'd like to suggest that you search Mayo Clinic Connect to see if anyone else has shared information about VAIN and the treatment you are prescribed. Here is how to do that.

Go to the top of this page. In the middle of the screen there is a Search window with an icon of a magnifying glass. Type various terms in that Search window such as VAIN or Vaginal intraepithelial neoplasia. You can also use the Search window for the cream you are using.

Also, @randinc11 would you like to share more about yourself? For instance, did you have symptoms? How was VAIN diagnosed? Was this during a routine gynecological exam? Did you doctor refer you to a specialist?

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