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@gently

HRT does both. It directly inhibits osteoclasts and prevents apoptosis of osteoblasts. It isn't fast the way Forteo or Tymlos or Evenity. I wonder how much it would hold gains after any one of the three.
I wonder what a transition from Evenity to Forteo would look like.
The chart from gutdad below is a little scary.
This from windyshores:
"In reply to @gently "Windyshores, your thoughts. Reclast after Prolia makes sense to me (though the use of Prolia does..." + (show)
@gently my doctor told me they aren't really sure how Evenity works. But they do know that it's anti-resorptive properties don't "lock in" gains from its anabolic action.

I think the effects of sclerostin inhibition are still not well-investigated and I believe Evenity isn't even a strong anti-resorptive (I have to double check that chart on CTX in last months) so there are mysteries here.

I don't think any research has been done on Forteo or Tymlos after Evenity. I was initially told that I could do Evenity after Tymlos or Forteo but not the other way around. At one point I read that the reason for this is that Evenity is so potent that there is little left for the other drugs to do.

I have only seen videos relating to Evenity after Tymlos or Forteo, never the other way around. We need more research! "
https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/treatment-after-evenity/

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Replies to "HRT does both. It directly inhibits osteoclasts and prevents apoptosis of osteoblasts. It isn't fast the..."

Thank you! That’s good to know about Forteo and Tymlos!

I’m a test case on following Evenity w HRT. I’m WAY behind schedule to start a follow up drug. I have terrible insurance. And I recently jumped through a lot of hoops to switch in order to get better care. The timing is bad, because I couldn’t get an appointment with an endocrinologist until October and a DXA scan until July 3.

Meanwhile, the previous rheumatologist had ordered Prolia. Who is supposed to be delivered on Wednesday but it wasn’t. I am an able to get anyone in the rheumatologist office to return my call. It’s frustrating. I’m hoping it turns out to be a blessing in disguise!