Seems like this is a common issue. I had mild osteoarthritis in one joint of one hand before PMR and Prednisone. The inflammation ramped up in both hands/wrists about a month after starting Prednisone and would hit at 1am as my morning dose of Prednisone was wearing off. I would walk around the house wailing in pain, begging someone to cut my hands off. Splitting the dose and taking half the morning dose at 5pm helped enormously. However the OA pain is now quite bad in both hands and both knees now that i am down to a 6mg daily dose of Prednisone and tapering successfully at 0.25mg per week. I take this as a positive sign that Prednisone no longer has me trapped because prior to this it was masking the OA pain. I can deal with the OA pain but the PMR pain was next level. I have been taking Hydroxychloroquine for the last 5 weeks and i think it is helping calm the PMR inflammation but is obviously not helping with the OA pain. I dont care, just want to rid myself of the dreaded steroids.