I got diagnosed with Stage 4 PDAC May 2023 with primary in pancreas body and numerous liver lesions. I had folfirinox for 6 rounds. The first few rounds were the worst and my oncologist tweaked the dosage to make it more tolerable. I ended up in emergency twice with the first 2 rounds…

When the neuropathy started in my hands, the oncologist swapped me over to gemcitabine and cisplatin for 2 rounds and then gem / carboplatin when the neuropathy got even worse. Bottom line is there are dosage and drug options which reduce the side effects. I was lucky in that I never got nausea but other common side effects such as diarrhoea and some fatigue.

My tumours and liver lesions shrank with each CT checkup until I took a 2 month chemo break when they started to grow again.

I am now onboarding onto a clinical trial which hopefully will be positive but it is a stage 1 so absolutely no guarantees it will help.

Good luck with the your husband’s journey. Bottom line there are multiple options and pathways.