Lupron therapy definitely does what is intended to do . A form of ‘chemical castrastion ‘ eliminates testosterone which feeds or fertilizes cancer cells . That being said muscle loss definitely so exercise is extremely important. Impotence may or may not happen but I believe it does in most cases I am waiting to hear from men who have finished the shots if they regain muscle and sexual potency doctors and nurses seem to not have the answers but hopefull this is after proton therapy did its job very minascule psa readings .I believe that prostate cancer should be given the same media treatment as breast cancer as it truly can devastate men and there quality of life and relationships thanks for this forum I hope it helps.