Non of us have. Of the many we know that are on it, no one has stated issues weight or otherwise. One of them is a savy "RN" who has tried it several different ways, straight Umary, a mix of Umary and hialuronic acid tabs, other mess that claim to have the same effect as Umary and none of them have been effective in reducing her arthritic pain as straight umary has been. The bottom line is what you are comfortable taking for yourself. We've had tremendous success, but you need to do what's best for you. Just remember, it's not a cure all for all joint pain. I have degenerative arthritis in my lower back that is debilitating at times. The Umary doesn't help with that. But the stiffness and pain in my hands is so much better. Also, it is not a cure, it is supplement like aspirin is, it helps but doesn't cure.