← Return to Bone turnover markers (CTX and P1NP): do you have a baseline?

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@debsinwa

Both of my numbers went up.
Before Forteo (August '23) they were P1NP: 45.9 and CTX: 444
6 months after started Forteo (April '24) they were P1NP: 220 and CTX: 1293
I am asking here for advice about these results. as I'm not sure either. I should have put in also that I had a compression fracture in spine in March and another in Sept. so that may also have had an effect on the numbers?

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Replies to "Both of my numbers went up. Before Forteo (August '23) they were P1NP: 45.9 and CTX:..."

From what I’ve read, a compression fracture can cause P1NP to rise. So, would Forteo. I do t think Forteo would raise CTX, not sure about fracture healing. From reading McCormick and listening to Lane Simpson, I think you want CTX to be 300-400. P1NP not on anabolic, 30-50, but it goes higher in anabolics as it should. My numbers aren’t terribly far from there and I still fractured. If you had lumbar fracture I highly recommend kyphoplasty. Helped with pain and quicker return to exercise.

@debsinwa this (fractures, sorry to hear that) changed things. I was puzzled by your high ctx at this stage of forteo. After a fracture, btms usually increase. And the degree and length of the increase depend on the size of the bone, the bmd of the fractured bone, the surface of the factured bone, the need for surgery and the degree of immobilization. So your btms results might have been influenced by the fractures. Most studies usually observe btms after a fracture for up to 1 year after fractures.

@sallyj2 ctx and p1np usually go in tandem during antiresorptive or anabolic therapy, due to coupling effect. In anabolic therapy, they are bit trickier to read.