@csm70
My husband developed PMR in May 2023 and GCA in February 2024. Since developing GCA he has been put on Actemra. His case was severe so they gave him three days of IV infusions of high-dose steroids (1200 mg) followed by daily doses of 80 mg Prednisone. He's tapered down to 50 mg at the moment with weekly Actemra injections.

I have not heard of Methotrexate so I can't comment on that. Can you ask your doctor if it would be safe to take only Prednisone and Actemra so you'd only have two meds?

I was doing a little research and found this on the Actemra info page about Methotrexate: https://www.actemra.com/ra/considerations/actemra-works-alone.html

I also found this info on drug and supplement interactions with the Methotrexate. I don't know about you, but our doctor doesn't always tell us things like this. https://www.nhs.uk/medicines/methotrexate/taking-methotrexate-with-other-medicines-and-herbal-supplements/#:~:text=Tell%20your%20doctor%20if%20you,other%20antibiotics%20for%20bacterial%20infections

One last thing. You might find this study interesting. It's on PMR but I would think could apply to GCA as well. I haven't finished reading but it appears to be saying that Actemra helps in faster prednisone tapering than with methotrexate and prednisone.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267957/