Hey @ihatecancer

It's a gut punch for certain. My father went through the same thing. I have the same cancer, luckily the treatment is much better than it was. I had the same treatment path as your father it seems.

I'd suggest maybe reading https://connect.mayoclinic.org/discussion/the-orgovyx-thread/

It's specific to Orgovyx (relugolix) but most ADT medicines have the same side effects. It's worked well for me. I'm about to go off of it for at least a while. So the "for life" hasn't really hit me yet. Given my family history, I may end up there as well.

It certainly does diminish your quality of life some, I won't overly sugarcoat it. My biggest side effect is really the hot flashes. Annoying and interferes with my sleep, which is not ideal. We try not to let it stop us. I work, workout aggressively, ride motorcycles, play with the grandkids. My feeling is though, if it will help me stick around to play with my grand young'ns, happy to put up with it. My goal is to dance at my granddaughters wedding. She's 8 LOL

It seems the best defense is activity. If your father is otherwise healthy, exercise seems to be the best medicine for combating the side effects. Walking, gardening, swimming etc.. all help. If he's young and healthy enough even light weight training can help combat some of the side effects.

When my father's cancer returned, he went on Lupron shots for years. The good news? he lived to be 92 and died of natural causes other than the cancer.

Best of luck to you and your family!