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Reclast after Forteo?

Osteoporosis & Bone Health | Last Active: May 28 12:34pm | Replies (42)

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@mayblin

@janflute All bisphosphonates have similar physiochemical properties, but their antiresorptive activities differ substantially. For example Reclast is stronger than fosamax, and fosamax is stronger than boniva or actonel. Then there are differences in the “stickiness” to bones among the bisphosphonates. Fosamax can stay in bone for up to 10 years. The length of the “stickiness” also depends on the rate of bone turnover. By comparison, the terminal life of risedronate/actonel is only 20 days.

Ask your endo to choose a sensible bisphosphonate for you, depending on your goals and strategy going forward, short and long term. I think the “gentleness” as well as the terminal life of each bisphosphonate will make a big difference, if you are going to have a second round of FORTEO.

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Replies to "@janflute All bisphosphonates have similar physiochemical properties, but their antiresorptive activities differ substantially. For example Reclast..."

Thank you. From reading your response, it seems that my dentist does not know as much about Fosamax vs Reclast as he seems. He told me that he wanted me to take Fosamax because when/if I need to have another tooth pulled there would be less problems with my jaw because I could stop taking Fosamax, but Reclast would be staying in my system. What do you think?

@mayblin it seems, from your posts, that Reclast might be best if we are satisfied with anabolic results and just want to "lock in" gains. But if we are not satisfied with results and have exhausted the active phase of an anabolic the first time around, and anticipate another round in the future, a weaker bisphosphonate might be best. Do you agree?

My doc is prescribing Reclast but also says I may do an anabolic in the future.