Hello all, this is my first post. I was on a low dose of Seroquel 25-75mg for 7 years. 8 months ago I was at a dose of 1+1/2 25 mg pills. I decided it just wasn't helping anymore and wanted to taper off. I started by continuing one 25 mg pill at night and taking the additional half every-other night. I did this for a week. Then I cut the half pill into a quarter. I did this for a few weeks to make sure I was ok. I didn't have any noticeable withdrawals. Then I cut back to just 25 mg at night for 2 or 3 weeks. Then started chipping away at the 25 mg pill a little more every few weeks as long as I felt ok. I got down to 1/4 of a 25 mg pill and rode that for about a month then cut it to every other night for a few weeks then quit. It's been 6 weeks now without Seroquel. I am a bit sensitive, I'm overstimulated easily but really not bad at all! I tapered very slowly. I do feel like I felt better when I quit the 1/4 pill. Going slow was so much better then in the past when I had to quit in a hurry due to the meds actually making me feel worse. They work great for a while but then they just don't work anymore. This was the longest I was on a med that worked for longer than a couple years. I do feel a little emotional or moody but the physical icky feeling isn't there. I am so grateful it wasn't a traumatic experience this time. I wish you all well!