That is not an option for hormone positive breast cancer patients.

It just goes to show every person is different. I have been using vaginal estradiol cream (inserted in the vagina and outer) from age 59 to 74. To renew my yearly RX prescription, hormone blood tests were required. The blood work included estradiol serum, progesterone/pregnenolone serum (< - test is questionable since I don't have a uterus), estrone serum , testosterone, DHEA, and estriol serum. Each year without exception my postmenopausal estradiol levels were so low they were undetectable. Maybe I'm an outlier? My testosterone, estrone, and DHA all had detectable amounts.
After reading the randomized trial I'm feeling confused. Soon I'll be using a .05 mg transdermal patch which is still considered on the low side. The trial used a vaginal 7.5ug, which is 40 times less than .05mg. 7.5ug is 17.5 times less than the lowest transdermal estradiol .025 patch. Should I conclude that vaginal estradiol is the superior absorption delivery method?
I am happy you had good results mlwh 🙂

Were you on any osteo medication or just HRT? Was the estradiol the only thing you were doing, was it a suppository and was it bioidentical or synthetic? This is really interesting information. How much improvement did u have on ur BMD? Thank you