Short and quick answer, nobody knows...

Think statistics and Bell Curve. Done are one, two or three standard deviations to the right (longer time to castrate resistance), others to the left.

Based on the clinical data you proved your post, does not seem you are a strong candidate for intermittent ADT.

However, you have options that may enable you to manage this as a "chronic" disease and die with it, not of it.

To start, you could switch to Orgovyx which has a lower side effect profile than Lupron. Note I did not say the side effects are different, but flashes, fatigue, mucked and joint stiffness...switching may be a function of insurance and any financial toxicity.

There are a dizzying array of options for both hormone sensitive and castrate resistant PCa, ARIs, PARP Inhibiters, Radio Isotopes, Chemotherapy...,

One thing to consider is have genomic testing done, the results may serve to guide future treatment decisions.

Heck, future radiation is not ruled out. When mine came back this time my radiologist said we could do SBRT to that PLN though we had done WPLN in 2017.

When you're bored, grab your favorite drink(s), mine is a Manhattan or Old Fashioned, and start reading the guidelines from organizations such as NCCN, AUA and patient handbooks such as the PCF has. It will be time well spent to inform and guide your discussions with your medical team.

Kevin

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