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Bone turnover markers (CTX and P1NP): do you have a baseline?
Osteoporosis & Bone Health | Last Active: Oct 5 5:35pm | Replies (183)Comment receiving replies
@mayblin. How often do we test for CTX and P1NP. I read to test before starting meds but how often do we test once we have started the meds? Specifically for Tymlos please. Thanks!
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A baseline P1NP and CTX for sure.
In a paper by Estell et al., results from ACTIVE showed early btms changes correlates to lumbar spine bmd changes at 18mo of abaloparatide (Tymlos). The initial P1NP increase is evident during 1-3mo. Trial data showed btms at 1,3,6,12 and 18mo. If your endo and insurance both offer tests, why not do them all? If you were to experience severe side effects and will need to ramp up dose as @windyshores described, likely you will get P1NP response at later months.
If your insurance only allows limited btm testing, and assuming you use max (80ug) or close to max dose at the beginning months, personally I’d chose 2 mo, 6 mo and 18mo (this one to determine if you want to continue use for a total of 24mo).