After IMRT, ultrasensitive PSA result < 0.03

Congratulations!

I went for surgery first in Feb-2022. I had EPE in the pathology report. After 14 months, recurrence started. My oncologist suggested two years of Zoledax and 20 rounds of radiation. It was my 3rd PSA result after radiation was completed in October 2023. Since then, I have been on Zoladex injection 10.8 and have taken four shots as of now.

So it could be because I am on Harmon. Once I stop, will it show PSA again?

Thanks

Congratulations.

That's a hard question to answer. I use a different medication for ADT (previously Firmagon, now Orgolyx) combined with an androgen-reception inhibitor (Erleada) to manage my stage 4 oligometastatic prostate cancer. I also had surgery and radiation to the metastasis, and 20 rounds of SBRT to the prostate itself. My PSA has remained below 0.01 on the ultra-sensitive test for 2½ years now.

Would my PSA start rising if I stopped? Would the cancer become castrate-resistant? Maybe not, but it doesn't feel like it's worth the risk of trying to find out. I'm just grateful for all these extra years I'm getting.

When there's a test for dormant cancer cells, I would consider stopping if the test showed there was no more cancer, but that's still at the research stage.

I’m in a similar situation.I started with Firmagon injections with 4x60mg Erleada for 2 and a half years.When I went to the Mayo I was told to cut the Erleada dose in half to 2 pills along with Lupron injections x 4 months.I find that this combination is working to keep my psa at less than 0.025.The problem is the side effects.I have a bad case of osteoarthritis.So far I’ve had 3 spinal vertebral compression fractures and I’m in a waiting list for my right hip surgical replacement.After 5 or 6 pm my muscles and joints stiffen up and any get up and go movement is painful even with analgesics.My orthopedic surgeon refused treating me due to my cancer even when MRI’s and bone density were good.As long as I’m walking on the grass and not lying underneath it I’ll soldier on.Does anyone have a similar osteoarthritic joints with muscle pain?I know exercise is part of the answer but it’s hard to start when you are unaware of your spinal limitations.I will try and get a referral with my family doctor or my oncologist to see if I can get help with my situation.

Hopefully your PSA will remain undetectable after the radiation and ADT wear off.
Following recurrence and salvage treatment of radiation together with ADT, my PSA 6 and 9 months following completion of treatment were undetectable at < .02 my next test is later this month.
Best wishes to us and to all.

Way to go Brother!! At my 3 month post SBRT and still on Orgovyx I was 0.09.

We got this!