Neuropathy + Proton-pump Inhibitor use?? Anyone had this experience?

Wow! I wonder how many people don't know about this! I've never had either of those procedures, but I'm sure at some point I probably will. I've started tapering off the PPI (Imeprazole) that I've taken foreger. Years ago my PCP had me switch from Imeprazole to Pepcid, and it didn't work for me. I'm wondering if after I get off of the PPI I'll be able to use Pepcid with success. Fingers crossed!

I am retired biomedic scientist I worked on the clinical development and launch of Prilosec in the US market. Many people and physicians, other than gastroenterologists, are still not familiar with the side effects that may occur in patients with long term use of acid suppressants like PPIs (prilosec etc) and H2RAs (pepcid etc).
The chronic suppression of acid secretion can cause a number of adverse events. One that is particularly problematic besides chronic gastrtis and gastric nodule formation are changes in the normal bacterial strains that colonize the normal gut (normal microbiome). Prolonged use of acid suppressants may cause the overgrowth of various deleterious bacterial species such as C. Difficile and others pathogenic strains. This may lead to severe diarrheal disease or small intestinal bacterial overgrowth (SIBO). This causes abdominal bloating, cramps, chronic diarrhea, malabsorption of nutrients and vitamins, and in severe cases, osteoporosis.
The initial treatments for these conditions is a course of antibiotics to eliminate the overgrowth and then replenishment of a normal microbiome via the use of various probiotics containing high colony forming units of healthy normal gut bacteria. In some more resistant cases the use of fecal transplant therapy (FTT) may be employed. This is a recently approved therapy where the patient is given several doses of capsules containing healthy gut bacteria that are collected from the fecal matter of a select healthy donor pool. While it sounds gross, it's quite effective. It also helps to diminish the sting of the well know curse "eat shit and die"😉
There other less noxious remedies one can try such as consumption of various fermented beverages such as kambucha or kefir which contain beneficial bacterial strains. The consumption of yogurts with fortified with various strains of bacteria to replenish a normal gut mmicrobiome has also been show to bei don't know here moderately effective in someI patients.
The consumption of a probiotics enriched in bacterial strains that produce short chain fatty acids (SCFAs), particularly butyrate, also has been shown to help restore balance to the gut-brain axis by modulation of both the enteric and central nervous system. SCFAs also have anti-inflammatory properties and down regulate the activation of microglial cells that drive neuroinflammation and small peripheral nerve fiber demyelination.
Returning to GERD, as many people on this forum with GERD have noted the difficulty in weaning themselves off their PPIs or H2RAs they’ve been taking for acid suppression. They often will experience rebound reflux and other GI discomfort if they try to quit “cold turkey” or slowly reduce their dosage. They must be slowly weaned off their acid suppressant in a gradual step wise fashion to hopefully avoid this.
While they are doing this there are a few safe and moderately effective OTC remedies the that they may find useful in aiding their withdrawal from acid suppressants. I had mentioned a few of these in my previous post but here’s a list of a few that GERD sufferers may want to try.
Consumption of non-dairy, plant based milks.
Drinking camomile, licorice or ginger teas, coconut water, aloe vera drinks and non acidic carrot or cucumber juices. All of these may help neutralize and partially suppress stomach acid production.
Chewing sugar free gum after a meal or during the day can stimulate siliva production that helps to temporarily neutralize stomach acid.
A tablespoon of baking soda dissolved in water will also provide temporary neutralization
Also the use of products that contain algenates such as Gaviscon will help form a barrier the floats atop of the gastric contents and forms a temporary barrier that prevents reflux of gastric contents into the esophagus.
Avoid fatty foods which may increase acid production and avoid caffinated beverages, colas carbonated beverages.
Lastly, avoid tobacco and nicotine containing products as well as dark chocolate as they all lower esophageal spincter opening pressures and exacerbate acid reflux.
I hope you find this information useful

I am retired biomedic scientist I worked on the clinical development and launch of Prilosec in the US market. Many people and physicians, other than gastroenterologists, are still not familiar with the side effects that may occur in patients with long term use of acid suppressants like PPIs (prilosec etc) and H2RAs (pepcid etc).
The chronic suppression of acid secretion can cause a number of adverse events. One that is particularly problematic besides chronic gastrtis and gastric nodule formation are changes in the normal bacterial strains that colonize the normal gut (normal microbiome). Prolonged use of acid suppressants may cause the overgrowth of various deleterious bacterial species such as C. Difficile and others pathogenic strains. This may lead to severe diarrheal disease or small intestinal bacterial overgrowth (SIBO). This causes abdominal bloating, cramps, chronic diarrhea, malabsorption of nutrients and vitamins, and in severe cases, osteoporosis.
The initial treatments for these conditions is a course of antibiotics to eliminate the overgrowth and then replenishment of a normal microbiome via the use of various probiotics containing high colony forming units of healthy normal gut bacteria. In some more resistant cases the use of fecal transplant therapy (FTT) may be employed. This is a recently approved therapy where the patient is given several doses of capsules containing healthy gut bacteria that are collected from the fecal matter of a select healthy donor pool. While it sounds gross, it's quite effective. It also helps to diminish the sting of the well know curse "eat shit and die"😉
There other less noxious remedies one can try such as consumption of various fermented beverages such as kambucha or kefir which contain beneficial bacterial strains. The consumption of yogurts with fortified with various strains of bacteria to replenish a normal gut mmicrobiome has also been show to bei don't know here moderately effective in someI patients.
The consumption of a probiotics enriched in bacterial strains that produce short chain fatty acids (SCFAs), particularly butyrate, also has been shown to help restore balance to the gut-brain axis by modulation of both the enteric and central nervous system. SCFAs also have anti-inflammatory properties and down regulate the activation of microglial cells that drive neuroinflammation and small peripheral nerve fiber demyelination.
Returning to GERD, as many people on this forum with GERD have noted the difficulty in weaning themselves off their PPIs or H2RAs they’ve been taking for acid suppression. They often will experience rebound reflux and other GI discomfort if they try to quit “cold turkey” or slowly reduce their dosage. They must be slowly weaned off their acid suppressant in a gradual step wise fashion to hopefully avoid this.
While they are doing this there are a few safe and moderately effective OTC remedies the that they may find useful in aiding their withdrawal from acid suppressants. I had mentioned a few of these in my previous post but here’s a list of a few that GERD sufferers may want to try.
Consumption of non-dairy, plant based milks.
Drinking camomile, licorice or ginger teas, coconut water, aloe vera drinks and non acidic carrot or cucumber juices. All of these may help neutralize and partially suppress stomach acid production.
Chewing sugar free gum after a meal or during the day can stimulate siliva production that helps to temporarily neutralize stomach acid.
A tablespoon of baking soda dissolved in water will also provide temporary neutralization
Also the use of products that contain algenates such as Gaviscon will help form a barrier the floats atop of the gastric contents and forms a temporary barrier that prevents reflux of gastric contents into the esophagus.
Avoid fatty foods which may increase acid production and avoid caffinated beverages, colas carbonated beverages.
Lastly, avoid tobacco and nicotine containing products as well as dark chocolate as they all lower esophageal spincter opening pressures and exacerbate acid reflux.
I hope you find this information useful

Hello, I have been taking Nexium for 10 years and for the past 2 years I’ve been experiencing neuropathic pain in my hands and now all over my body.

All my blood tests come back fine, including my B12 levels. I stopped taking the ppi one week ago and notice no improvements.

I hope you feel better.

Thank you so much for all your info. I have what they call chemo induced neuropathy. Oncologists told me it would go away when treatment was done and here I am going on two years and it is getting worse. Gabapentin for a year and stopped, my memory is getting so bad due to the Gabapentin. No one offers any solutions and I am left to deal with the neuropathy on my own. Your information is most helpful. I had heard about too much anti acids so I am trying to stay off of them. I will definitely try some of your recommendations. Anymore info is appreciated. Thank you.

I have been on a proton pump inhibitor for years this reduces acid in the stomach and now I am suffering from peripheral neuropathy. I will be very interested how you get on.

I have been on a proton pump inhibitor for years this reduces acid in the stomach and now I am suffering from peripheral neuropathy. I will be very interested how you get on.