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Prolia adverse events over 10 years - ONJ, AFF

Osteoporosis & Bone Health | Last Active: Apr 30 4:14pm | Replies (18)
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@normahorn

WindyShores reminded me of this previous post. In considering medications, I feel it is important to consider the whole person and not just the bones. Some of us cannot afford to have our immune systems negatively affected.
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I found this about immune system being affected. I wish it were from a source such as Mayo or Cleveland Clinic.
https://www.drugs.com/medical-answers/prolia-weaken-immune-system-3553497/

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Replies to "WindyShores reminded me of this previous post. In considering medications, I feel it is important to..."
Michael Lavacot | @michaellavacot | Apr 30 4:01pm

I have heard of the urinary tract infection indication and hypocalcemia is definitely possible if you don't have adequate calcium intake (first hand knowledge here), there was also a small but significant cellulitis events in the main Freedom trial. I have not heard of the other adverse effects called out on the site you listed.

Attached is a slide that was also presented at WCO 2024 showing infection adverse events from the Freedom study. There were not any big standouts here. ~3880 participants in each group.
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