The only non-opioid I have been using that seems to reduce the severity of my pain is a supplement of anti-oxidants. I don't remember the exact name, but it contains vitamins A, C, D, E and selenium. I don't know if this provides any immediate relief, but over my first month I am having significantly fewer flares or days where my pain level reaches 8-10. That was happening 4-5 days every week for many hours of the day. As with anything you take, you should check it against other meds for interactions. I know that these type of suggestions really irritate me when my pain is at 9 and someone says this may help in a couple of weeks, but I just don't know any better suggestion.