I am on the Gem Abraxane protocol for peritoneal metastatic lesions from pancreatic cancer and have done most of my doses every two weeks. I could not tolerate the three weeks on, one off routine. I also had to have the dosages reduced by 20%. I weigh about 106 on a good day! My C19-9 is down from 496 to 37 and I have a repeat PetScan scheduled in two weeks. I hope it is great!!