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Prolia adverse events over 10 years - ONJ, AFF
Osteoporosis & Bone Health | Last Active: Aug 19 1:57pm | Replies (19)Comment receiving replies
Yeah, stopping is a bit tricky. If your non-treatment baseline CTX is high, you can expect a greater rebound effect than if it's low. And if you have been on Prolia longer than about 2.5 years, you have to plan on losing about 0.5 T-score after transitioning to a bisphosphonate. I plan on staying on Prolia until I reach about -1.0 to account for the rebound.
Replies to "Yeah, stopping is a bit tricky. If your non-treatment baseline CTX is high, you can expect..."
Michael , I transitioned from Evenity to Prolia and had my DEXA yesterday. It went from T score in the spine -3.3 after Evenity to -3.2 after one year of Prolia. Needless to say that I’m very disappointed. Have you heard of many cases where Prolia failed?
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My doctors don't use Prolia unless there are absolutely no other options. My endo joked that he might prescribe it near retirement so he doesn't have to deal with anyone trying to get off!
@Michael Lavacot, -1.0 or even -2.0 is out of reach for many of us. No matter what I do, I will never get better scores than -2.5 in spine and femur neck will remain -3.5 or so. So many of us cannot afford to "plan on losing about 0.5 T score after transitioning to a bisphosphonate."
It is not just about bone density changes: it is about increased fracture risk as well.
I am not sure if there is more risk for females past menopause who no longer have much estrogen vs a male. Have you researched that?
The relative safety of 2-3 injections of Prolia in terms of rebound in showing up more on this forum and apparently McCormick encourages this. That is encouraging, because Dr. Ben Leder's video on YouTube shows how very effective Prolia can be, on its own or in a complicated combination with anabolic that he demonstrates. Again, until you stop.