Hi Coleen, She has been on Remacaid for 2 1/2 yrs. since then. This Dr. had also had her on a lower dose and also on a drug called Uceris. She was having some strong side effects from that drug where she often had confusional episodes especially in the evening like she had been drinking and she had not? She was taken off this drug and the Remacaid dose was increased and as I said other than some morning issues she has been back to doing well. I have some concerns from the long term effects of Remacaid, but it is providing the help that my wife desperately needed and I guess that's what really matters. Any feedback would be greatly appreciated.