I just finished 12 months of Orgovyx, came off it on 4 April.

I took mine each night around 11 pm.

Fatigue, yes, mornings were ok, late afternoons and evenings, very noticeable.

I exercised pretty much every day, either at the gym riding the indoor bike, lifting weights, swimming, outside, riding my bike, playing pickleball, active vacations such as skiing and hiking in Colorado, gardening chores, walking our dog (A yorkie who loves to sniff so average pace was 35 minutes a mile, was it really "exercise!?")....

My wife will tell you, there were times where I just took the damn nap!

Interestingly, been off it three weeks, fatigue and muscle and joint stiffness more or less gone, the hot flashes, the inverse, more and more severe, ugh. It will be interesting to see what my T is at the three month labs and consultation, started at 600+.

Like others, a study of one...

Kevin